Complement receptor is an inhibitor of the complement cascade.

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Complement receptor is an inhibitor of the complement cascade

A glycoprotein from the membrane of human erythrocytes has been identified as a receptor for C3b (CR1). It promotes the dissociation of the alternative pathway C3 convertase C3b,Bb and the cleavage of C3b by C3b/C4b inactivator. We find that CR1 also inactivates the C3 and C5 convertases of the classical pathway. CR1 inhibits the consumption of C3 by C3 convertase EAC142 and enhances the decay ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1981

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.153.5.1138